Glucocerebrosidase: reconstitution from macromolecular components depends on acidic phospholipids.
نویسندگان
چکیده
The reconstitution of glucocerebrosidase activity from its inactive macromolecular components depended on acidic membrane phospholipids.
منابع مشابه
Activators of spleen glucocerebrosidase from controls and patients with various forms of Gaucher's disease.
Glucocerebrosidase from normal human spleen, and spleen from cases of neurologic (types 2 and 3) and nonneurologic (type 1) Gaucher's disease, was delipidated and inactivated by extraction from membranes with sodium cholate and ice-cold 1-butanol. Control glucocerebrosidase was stimulated markedly by large quantities (20-30 micrograms/assay) of phosphatidylserine (PS), or by a combination of sm...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 136 3 شماره
صفحات -
تاریخ انتشار 1973